Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237230 | 0.88 | MAPK1 (0.54) | MAPK1POLBTSHRMEN1KMT2A | |
| SCHEMBL16797504 | 0.82 | MAPK1 (0.81) | MAPK1POLBTSHRMEN1KMT2A | |
| SCHEMBL13479227 | 0.82 | POLB (0.51) | MAPK1POLBTSHRMEN1KMT2A | |
| SCHEMBL30219287 | 0.81 | SMN1; SMN2 (0.57) | MAPK1POLBTSHRMEN1KMT2A | |
| SCHEMBL11408239 | 0.81 | GAA (0.65) | MAPK1POLBTSHRMEN1KMT2A | |
| SCHEMBL29598834 | 0.81 | GAA (0.65) | MAPK1POLBTSHRMEN1KMT2A | |
| SCHEMBL3344597 | 0.81 | SMN1; SMN2 (0.57) | MAPK1POLBTSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31532317 | 0.80 | SMN1; SMN2 (0.56) | MAPK1POLBTSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11537120 | 0.80 | GAA (0.63) | MAPK1POLBTSHRMEN1KMT2A | |
| SCHEMBL3285978 | 0.80 | MEN1 (0.49) | MAPK1POLBTSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940835-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007036733-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |