Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | STAT6 | P42226 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30219287 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNATSHRADRA2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL31532317 | 0.98 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL12505411 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL11408239 | 0.87 | GAA (0.65) | SMN1; SMN2LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL29598834 | 0.87 | GAA (0.65) | SMN1; SMN2LMNATSHRADRA2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL28335606 | 0.85 | MEN1 (0.52) | SMN1; SMN2TSHRGAAMEN1KMT2A | |
| SCHEMBL3285978 | 0.85 | MEN1 (0.49) | SMN1; SMN2LMNATSHRGAAMEN1 | |
| Hydrochloric Acid SCHEMBL11537120 | 0.85 | GAA (0.63) | SMN1; SMN2LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL8261355 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL987275 | 0.85 | LMNA (0.60) | SMN1; SMN2LMNATSHRADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393781-B1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | disclosed |
| US-20100160388-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160388-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | P2RY1, P2RX1, P2RX3 | SMN1; SMN2 2596/4885LMNA 2320/4885TSHR 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.