Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.58 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31452806 | 0.94 | NCOA1 (0.68) | KMT2ALMNAHTTNPSR1NCOA1 | |
| SCHEMBL30451554 | 0.85 | KCNH2 (0.63) | KMT2ALMNAHTTNPSR1NCOA1 | |
| SCHEMBL29014967 | 0.85 | KCNH2 (0.63) | KMT2ALMNAHTTNPSR1NCOA1 | |
| SCHEMBL30046414 | 0.81 | DGAT1 (0.61) | KMT2ALMNAHTTNPSR1NCOA1 | |
| SCHEMBL20522402 | 0.81 | DGAT1 (0.61) | KMT2ALMNAHTTNPSR1NCOA1 | |
| SCHEMBL14874681 | 0.80 | KMT2A (0.56) | KMT2ALMNAHTTNPSR1NCOA1 | |
| SCHEMBL24363131 | 0.77 | KMT2A (0.56) | KMT2ALMNAHTTNPSR1NCOA1 | |
| SCHEMBL14874651 | 0.77 | KMT2A (0.49) | KMT2ALMNAHTTNPSR1NCOA1 | |
| SCHEMBL10840568 | 0.76 | KMT2A (0.51) | KMT2ALMNAHTTNPSR1NCOA1 | |
| SCHEMBL22672408 | 0.76 | NPSR1 (1.00) | KMT2ALMNAHTTNPSR1NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917244-A2 | HETARYL-SUBSTITUTED GUANIDINE COMPOUNDS AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5-RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022964-A2 | HETARYL-SUBSTITUTED GUANIDINE COMPOUNDS AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5-RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |