Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29162704 | 0.84 | KDM4E (0.39) | PIK3CDKMT2AKDM4EHRH3ALDH1A1 | |
| SCHEMBL10263815 | 0.82 | PIK3CD (0.52) | PIK3CDCYP1A2TDP1KMT2AKDM4E | |
| SCHEMBL11224155 | 0.80 | ALDH1A1 (0.37) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL21096753 | 0.80 | — | — | |
| SCHEMBL27461646 | 0.79 | GPR183 (0.40) | KMT2AKDM4EDRD3GPR183 | |
| SCHEMBL23449305 | 0.78 | PIK3CD (0.48) | PIK3CDCYP1A2TDP1KMT2AKDM4E | |
| SCHEMBL19701915 | 0.77 | PIK3CD (0.50) | PIK3CDCYP1A2TDP1KMT2AKDM4E | |
| SCHEMBL22212138 | 0.77 | PIK3CD (0.50) | PIK3CDCYP1A2TDP1KMT2AKDM4E | |
| SCHEMBL1105150 | 0.76 | CYP1A2 (0.54) | PIK3CDCYP1A2TDP1KMT2AKDM4E | |
| SCHEMBL20847001 | 0.75 | USP2 (0.47) | KMT2ASMN1; SMN2HRH3USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |