Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | MARS1 | P56192 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913172 | 0.89 | NPC1 (0.41) | SMN1; SMN2EGLN2NPC1MAOBKDM4C | |
| SCHEMBL338815 | 0.85 | ALPL (0.44) | EGLN2NPC1ALPLMAOB | |
| SCHEMBL28503211 | 0.80 | MAOB (0.44) | ALDH1A1TP53TSHRCASP1SMN1; SMN2 | |
| SCHEMBL4196947 | 0.79 | EGLN2 (0.38) | EGLN2NPC1MAOBMARS1RAB9A | |
| SCHEMBL4767528 | 0.79 | CNR1 (0.40) | TSHRSMN1; SMN2NPC1MAOB | |
| SCHEMBL338509 | 0.78 | TDP1 (0.41) | ALDH1A1EGLN2NPC1MAOBKDM4E | |
| SCHEMBL339621 | 0.78 | EGLN2 (0.41) | EGLN2NPC1MAOB | |
| SCHEMBL1913156 | 0.78 | EGLN2 (0.41) | EGLN2NPC1KDM4E | |
| SCHEMBL29229563 | 0.76 | MAOB (0.43) | ALDH1A1TP53TSHRCASP1SMN1; SMN2 | |
| SCHEMBL339104 | 0.75 | KDM4E (0.45) | EGLN2NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004643-A1 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007113226-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |