Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 3/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722485 | 0.90 | HTR1B (0.41) | HTR1BHTR1DHTR2CHTR2BDRD2 | |
| SCHEMBL4722451 | 0.89 | TP53 (0.44) | HTR1BHTR1DSLC6A4HRH1 | |
| SCHEMBL4720305 | 0.88 | ENPP1 (0.38) | ENPP1HTR1BHTR1DHTR2AHTR2C | |
| SCHEMBL4720531 | 0.87 | FABP7 (0.40) | HTR2ASLC6A4 | |
| SCHEMBL4723946 | 0.80 | ALDH1A1 (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL4721222 | 0.78 | HTR1B (0.40) | HTR1BHTR1DHTR2CHTR2BDRD2 | |
| SCHEMBL4720812 | 0.77 | TP53 (0.43) | HTR1BHTR1DSLC6A4HRH1 | |
| SCHEMBL4723599 | 0.74 | FABP7 (0.39) | — | |
| SCHEMBL45343 | 0.70 | HTR1B (0.61) | HTR1BHTR1DSLC6A4HRH1TSHR | |
| SCHEMBL4720536 | 0.69 | HTR2C (0.37) | HTR2AHTR2CHTR2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874780-A1 | 4-PIPERAZINYLTHIENO[2,3-D]PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006100591-A1 | 4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-09-28 | — | — | WO | disclosed |