Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 7/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | QPCTL | Q9NXS2 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrolidine SCHEMBL4769098 | 0.98 | QPCT (0.48) | QPCTPRKCIPARP1MAPTKDM4E | |
| Piperidine SCHEMBL4768366 | 0.87 | PARP1 (0.41) | QPCTPRKCIPARP1MAPTKDM4E | |
| SCHEMBL903277 | 0.86 | PRKCI (0.59) | QPCTPRKCIPARP1MAPTKDM4E | |
| Pyrrolidine SCHEMBL4767526 | 0.85 | PARP1 (0.42) | QPCTPRKCIPARP1MAPTKDM4E | |
| Piperidine SCHEMBL4766187 | 0.81 | QPCT (0.47) | QPCTPRKCIPARP1MAPTKDM4E | |
| Pyrrolidine SCHEMBL4768471 | 0.79 | QPCT (0.48) | QPCTPRKCIPARP1MAPTKDM4E | |
| Pyrrolidine SCHEMBL4724680 | 0.79 | PRKCI (0.47) | QPCTPRKCIPARP1MAPTKDM4E | |
| Benzimidazole SCHEMBL739311 | 0.76 | SMN1; SMN2 (0.39) | QPCTPRKCIPARP1MAPTKDM4E | |
| Methylethylamine SCHEMBL4767397 | 0.74 | QPCT (0.50) | QPCTPRKCIPARP1MAPTKDM4E | |
| Benzimidazole SCHEMBL4553022 | 0.74 | SMN1; SMN2 (0.40) | QPCTPRKCIPARP1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |