Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721133 | 0.93 | MAPT (0.56) | MAPTNPSR1MAPK1HTTHTR6 | |
| SCHEMBL4721402 | 0.86 | MAPT (0.49) | MAPTNPSR1MAPK1HTTHTR6 | |
| SCHEMBL4722686 | 0.86 | NPSR1 (0.65) | MAPTNPSR1MAPK1HTTHTR6 | |
| SCHEMBL4724273 | 0.85 | MAPT (0.59) | MAPTNPSR1MAPK1HTTHTR6 | |
| SCHEMBL4719397 | 0.84 | MAPT (0.56) | MAPTNPSR1MAPK1HTTHTR6 | |
| SCHEMBL4722721 | 0.84 | MAPT (0.56) | MAPTNPSR1MAPK1HTTHTR6 | |
| SCHEMBL4722092 | 0.82 | MAPT (0.66) | MAPTNPSR1MAPK1HTTHTR6 | |
| SCHEMBL4723139 | 0.81 | MAPT (0.82) | MAPTNPSR1MAPK1HTTHTR6 | |
| SCHEMBL4723562 | 0.81 | MAPT (0.45) | MAPTNPSR1MAPK1HTTHTR6 | |
| SCHEMBL4720715 | 0.81 | MAPT (0.46) | MAPTNPSR1MAPK1HTTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |