Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 4/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3827915 | 1.00 | ADRB2 (0.42) | ADRB2STAT3KCNH2KDM4EALDH1A1 | |
| SCHEMBL3832937 | 1.00 | ADRB2 (0.42) | ADRB2STAT3KCNH2KDM4EALDH1A1 | |
| SCHEMBL4723488 | 0.93 | KCNH2 (0.43) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2838588 | 0.82 | ADRB2 (0.46) | ADRB2STAT3KCNH2KDM4EALDH1A1 | |
| SCHEMBL584972 | 0.82 | ADRB2 (0.46) | ADRB2STAT3KCNH2KDM4EALDH1A1 | |
| SCHEMBL584819 | 0.80 | ADRB2 (0.43) | ADRB2STAT3KCNH2KDM4EALDH1A1 | |
| SCHEMBL3054226 | 0.80 | ADRB2 (0.43) | ADRB2STAT3KCNH2KDM4EALDH1A1 | |
| SCHEMBL584190 | 0.80 | ADRB2 (0.43) | ADRB2STAT3KCNH2KDM4EALDH1A1 | |
| SCHEMBL1984659 | 0.75 | ADRB2 (0.58) | ADRB2STAT3KCNH2KDM4EALDH1A1 | |
| SCHEMBL1344946 | 0.75 | ADRB2 (0.58) | ADRB2STAT3KCNH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931684-A2 | OXAZOLIDINONE-QUINOLONE HYBRIDS AS ANTIBACTERIAL COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007017828-A2 | OXAZOLIDINONE-QUINOLONE HYBRIDS AS ANTIBACTERIAL COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-02-15 | — | — | WO | disclosed |