Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | EYA2 | O00167 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edetic Acid SCHEMBL9067296 | 0.94 | ALDH1A1 (0.62) | ALDH1A1TDP1EYA2APPACE | |
| Edetic Acid SCHEMBL1684283 | 0.91 | ALDH1A1 (0.65) | ALDH1A1TDP1EYA2APPACE | |
| Edetic Acid SCHEMBL9707163 | 0.91 | ALDH1A1 (0.65) | ALDH1A1TDP1EYA2APPACE | |
| Edetic Acid SCHEMBL17162123 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TDP1EYA2APPACE | |
| Edetic Acid SCHEMBL21433561 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TDP1EYA2APPACE | |
| Edetic Acid SCHEMBL7761651 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TDP1EYA2APPACE | |
| Edetic Acid SCHEMBL2923973 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TDP1EYA2APPACE | |
| Pentetic Acid SCHEMBL8606808 | 0.89 | KDM4E (0.62) | ALDH1A1TDP1EYA2APPACE | |
| Edetic Acid SCHEMBL5727736 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TDP1EYA2APPACE | |
| Edetic Acid SCHEMBL27691408 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TDP1EYA2APPACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096784-A1 | Composition for Cleaning Dental Instruments and Process | VOCO GMBH (DE) | 2008-04-24 | — | — | US | disclosed |
| EP-1872122-A2 | USE OF PHOSPHONAZO III FOR THE MEASUREMENT OF CALCIUM, MAGNESIUM AND SODIUM IN ANALYTICAL SAMPLES | Specialty Assays, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| US-7288414-B2 | Use of phosphonazo III for the measurement of calcium, magnesium and sodium in analytical samples | SPECIALTY ASSAYS, INC. (US) | 2007-10-30 | — | — | US | disclosed |
| WO-2006113477-A2 | USE OF PHOSPHONAZO III FOR THE MEASUREMENT OF CALCIUM, MAGNESIUM AND SODIUM IN ANALYTICAL SAMPLES | SPECIALTY ASSAYS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |
| US-20060234384-A1 | Use of phosphonazo III for the measurement of calcium, magnesium and sodium in analytical samples | SPECIALTY ASSAYS, INC. | 2006-10-19 | — | — | US | disclosed |
| EP-0124143-B2 | PROCESS FOR THE PREPARATION OF AN ANTI-CORROSIVE AQUEOUS LIQUID DETERGENT COMPOSITION | UNILEVER N.V. (NL) | 1992-07-01 | — | — | EP | disclosed |
| US-4774258-A | Treatment of urinary calculi | RUBIN MARTIN (US) | 1988-09-27 | — | — | US | disclosed |
| US-4774257-A | Treatment of urinary calculi | RUBIN MARTIN (US) | 1988-09-27 | — | — | US | disclosed |
| EP-0080223-A2 | Enzymatic liquid detergent composition | UNILEVER N.V. (NL) | 1983-06-01 | — | — | EP | disclosed |