Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 3/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | WHR1 | P49842 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26102836 | 0.92 | KDM1A (0.53) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL26098937 | 0.92 | KIT (0.56) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL4782102 | 0.90 | WHR1 (0.61) | EGFRKDM4ELMNAHPGDHTT | |
| SCHEMBL26101213 | 0.87 | ABCG2 (0.53) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL26099045 | 0.84 | PDGFRB (0.51) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL10296331 | 0.84 | IRAK1 (0.68) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL16281244 | 0.84 | KDM1A (0.60) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL8499854 | 0.83 | EGFR (0.52) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL14417895 | 0.83 | KDM1A (0.58) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL295891 | 0.83 | ENPP1 (0.68) | KDM1AIRAK1IRAK4EGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |