Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 15/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 2/20 | 0.53 |
| ▸ | IDH2 | P48735 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4880977 | 0.91 | AURKA (0.54) | AURKAMAPK8FAAH | |
| SCHEMBL4779915 | 0.91 | AURKA (0.52) | AURKAMAPK8FAAH | |
| SCHEMBL4884947 | 0.90 | AURKA (0.56) | AURKAMAPK8FAAHIDH2 | |
| SCHEMBL4725708 | 0.90 | AURKA (0.56) | AURKAMAPK8IDH2 | |
| SCHEMBL14292067 | 0.88 | MEN1 (0.50) | AURKAFAAH | |
| SCHEMBL14292066 | 0.88 | AURKA (0.55) | AURKAMAPK8FAAH | |
| SCHEMBL14292790 | 0.88 | EGFR (0.56) | AURKAMAPK8 | |
| SCHEMBL14292648 | 0.88 | AURKA (0.53) | AURKAMAPK8FAAH | |
| SCHEMBL4880768 | 0.86 | FAAH (0.51) | AURKAMAPK8FAAH | |
| SCHEMBL14292483 | 0.86 | AURKA (0.48) | AURKAMAPK8FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |