Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 15/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 14/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 7/20 | 1.00 |
| ▸ | CHRNB1 | P11230 | 6/20 | 1.00 |
| ▸ | CHRNB3 | Q05901 | 6/20 | 1.00 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.87 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.70 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2501426 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 | |
| Hydrochloric Acid SCHEMBL6585118 | 0.99 | CHRNB2 (0.98) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 | |
| SCHEMBL14941055 | 0.93 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 | |
| SCHEMBL14941054 | 0.93 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 | |
| SCHEMBL6583548 | 0.90 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 | |
| Hydrochloric Acid SCHEMBL6585308 | 0.89 | CHRNB2 (0.98) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 | |
| SCHEMBL8305152 | 0.87 | CHRNB2 (0.77) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 | |
| SCHEMBL12190816 | 0.87 | CHRNB2 (0.77) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 | |
| SCHEMBL12190815 | 0.85 | CHRNB2 (0.81) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 | |
| SCHEMBL13308403 | 0.85 | CHRNB2 (0.74) | CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642612-B2 | Nicotinic desensitizers and methods of selecting, testing, and using them | POTOMAC PHARMACEUTICALS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| WO-2008011484-A2 | NICOTINIC DESENSITIZERS AND METHODS OF SELECTING, TESTING, AND USING THEM | BETHESDA PHARMACOLOGY ASSOCIATES, LLC (US) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008011484-A2 | NICOTINIC DESENSITIZERS AND METHODS OF SELECTING, TESTING, AND USING THEM | BETHESDA PHARMACOLOGY ASSOCIATES, LLC (US) | 2008-01-24 | — | — | WO | disclosed |