Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629582 | 0.92 | PIK3CG (0.48) | PIK3CGHRH4BACE1NR4A2LMNA | |
| SCHEMBL1463404 | 0.80 | HRH4 (0.40) | PIK3CGHRH4BACE1HTR3A | |
| SCHEMBL29580471 | 0.79 | ALDH1A1 (0.55) | PIK3CGHRH4NR4A2LMNACYP1A2 | |
| SCHEMBL346120 | 0.79 | ALDH1A1 (0.55) | PIK3CGHRH4NR4A2LMNACYP1A2 | |
| Ammonia Solution, Strong SCHEMBL28148393 | 0.78 | ALDH1A1 (0.53) | PIK3CGHRH4NR4A2LMNACYP1A2 | |
| SCHEMBL31649418 | 0.77 | HRH4 (0.45) | PIK3CGHRH4NR4A2LMNACYP1A2 | |
| SCHEMBL2609314 | 0.77 | HRH4 (0.49) | PIK3CGHRH4NR4A2LMNACYP1A2 | |
| SCHEMBL11372767 | 0.77 | ALDH1A1 (0.42) | BACE1PDGFRBPDGFRADYRK1A | |
| SCHEMBL2616096 | 0.76 | HRH4 (0.55) | PIK3CGHRH4NR4A2LMNAMAPT | |
| SCHEMBL14322277 | 0.76 | HRH4 (0.47) | PIK3CGHRH4NR4A2CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008015423-A1 | QUINOLINE AND QUINOXALINE N-OXIDES AS CHK-1 INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008015423-A1 | QUINOLINE AND QUINOXALINE N-OXIDES AS CHK-1 INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2008-02-07 | — | — | WO | disclosed |
| US-RE30563-E | Preparation of benzoylureas | ELI LILLY AND COMPANY (US) | 1981-03-31 | — | — | US | disclosed |
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4133956-A | Preparation of benzoylureas | ELI LILLY AND COMPANY (US) | 1979-01-09 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |