Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.36 |
| ▸ | EPM2A | O95278 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN3 | P26045 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16673211 | 0.79 | FFAR1 (0.49) | FFAR1RXRARXRBRXRGGAA | |
| SCHEMBL27367665 | 0.77 | FFAR1 (0.63) | FFAR1RXRARXRBRXRGALDH1A1 | |
| SCHEMBL670658 | 0.77 | FFAR1 (0.52) | FFAR1HSP90AA1NTSR1ALDH1A1L3MBTL1 | |
| SCHEMBL30772315 | 0.75 | HSP90AA1 (0.48) | FFAR1HSP90AA1NTSR1ALDH1A1L3MBTL1 | |
| SCHEMBL17974963 | 0.75 | FFAR1 (0.47) | FFAR1RXRARXRBRXRGGAA | |
| SCHEMBL96814 | 0.74 | FFAR1 (0.46) | FFAR1RXRARXRBRXRGGAA | |
| SCHEMBL3161990 | 0.74 | FFAR1 (0.52) | FFAR1GAAHSP90AA1NTSR1ALDH1A1 | |
| SCHEMBL12469659 | 0.73 | L3MBTL1 (0.53) | GAAALDH1A1L3MBTL1PTGDR2 | |
| SCHEMBL8307304 | 0.71 | FFAR1 (0.47) | FFAR1RXRARXRBRXRGGAA | |
| SCHEMBL2292901 | 0.71 | PTGDR2 (0.46) | FFAR1HSP90AA1NTSR1ALDH1A1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937641-A2 | DIHYDRO-[1H]-QUINOLIN-2-ONE DERIVATIVES AS RXR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEROLEMIA AND DIABETES | Janssen Pharmaceutica, N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007041112-A2 | DIHYDRO-[1H]-QUINOLIN-2-ONE DERIVATIVES AS RXR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEROLEMIA AND DIABETES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-12 | — | — | WO | disclosed |