Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726316 | 0.83 | PTPN1 (0.38) | L3MBTL1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL6000167 | 0.82 | PTPN1 (0.49) | L3MBTL1RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL4726976 | 0.81 | PTPN1 (0.36) | L3MBTL1RAB9ANPC1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL5999810 | 0.80 | PTPN1 (0.36) | L3MBTL1RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL6000965 | 0.80 | PTPN1 (0.40) | L3MBTL1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL6000020 | 0.80 | PTPN1 (0.48) | MAPTPTPN1PTPN2ALOX5 | |
| SCHEMBL4730043 | 0.79 | PTPN1 (0.41) | L3MBTL1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL4729099 | 0.79 | PTPN1 (0.37) | L3MBTL1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL6000861 | 0.79 | PTPN1 (0.52) | L3MBTL1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL6000958 | 0.79 | PTPN1 (0.44) | L3MBTL1RAB9ANPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033932-A2 | BIARYLTHIAZOLE CARBOXYLIC ACID DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASE-IB INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033932-A2 | BIARYLTHIAZOLE CARBOXYLIC ACID DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASE-IB INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |