Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CD74 | P04233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726316 | 0.92 | PTPN1 (0.38) | PTPN1PTPN2ACVRL1ADRB3ALDH1A1 | |
| SCHEMBL4729235 | 0.89 | PTPN1 (0.37) | PTPN1PTPN2ADRB3ALDH1A1RAB9A | |
| SCHEMBL4726976 | 0.85 | PTPN1 (0.36) | PTPN1PTPN2ADRB3ALDH1A1RAB9A | |
| SCHEMBL4781642 | 0.85 | MAPT (0.46) | ALDH1A1RAB9AL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5999810 | 0.84 | PTPN1 (0.36) | PTPN1PTPN2ADRB3ALDH1A1RAB9A | |
| SCHEMBL4730043 | 0.83 | PTPN1 (0.41) | PTPN1PTPN2ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL14261198 | 0.81 | ALDH1A1 (0.37) | PTPN1PTPN2ADRB3ALDH1A1RAB9A | |
| SCHEMBL6000635 | 0.80 | PTPN1 (0.49) | PTPN1PTPN2L3MBTL1MEN1KMT2A | |
| SCHEMBL6000424 | 0.80 | PTPN1 (0.41) | PTPN1PTPN2ADRB3ALDH1A1RAB9A | |
| SCHEMBL4730045 | 0.79 | PTPN1 (0.34) | PTPN1PTPN2ALDH1A1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |