Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725821 | 1.00 | MEN1 (0.42) | MEN1KMT2AAKR1C3NFKB1NFKB2 | |
| SCHEMBL28723296 | 0.85 | MEN1 (0.44) | MEN1KMT2AAKR1C3ABCG2RECQL | |
| SCHEMBL2409609 | 0.85 | ABCG2 (0.47) | MEN1KMT2AAKR1C3NFKB1NFKB2 | |
| SCHEMBL28251565 | 0.83 | AKR1C3 (0.43) | MEN1KMT2AAKR1C3NFKB1NFKB2 | |
| SCHEMBL28178758 | 0.82 | MEN1 (0.44) | MEN1KMT2AAKR1C3NFKB1NFKB2 | |
| SCHEMBL4649011 | 0.81 | AKR1C3 (0.47) | MEN1KMT2AAKR1C3ALDH1A1TSHR | |
| SCHEMBL13241270 | 0.81 | MEN1 (0.58) | MEN1KMT2AAKR1C3NFKB1NFKB2 | |
| SCHEMBL4649014 | 0.81 | AKR1C3 (0.47) | MEN1KMT2AAKR1C3ALDH1A1TSHR | |
| SCHEMBL7153123 | 0.81 | AKR1C3 (0.47) | MEN1KMT2AAKR1C3ALDH1A1TSHR | |
| SCHEMBL7615069 | 0.80 | AKR1C3 (0.50) | MEN1KMT2AAKR1C3NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937640-A2 | 1,2,3,5-TETRAHYDRO-CYCLOPENTAL[C]QUINOLIN-4-ONE DERIVATIVES AS RXR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEROLEMIA AND DIABETES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007041076-A2 | 1,2,3,5-TETRAHYDRO-CYCLOPENTAL[C]QUINOLIN-4-ONE DERIVATIVES AS RXR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEROLEMIA AND DIABETES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-12 | — | — | WO | disclosed |