Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.76 |
| ▸ | RAB9A | P51151 | 8/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.76 |
| ▸ | TP53 | P04637 | 3/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.73 |
| ▸ | RELA | Q04206 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033067 | 0.86 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL13171356 | 0.78 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL4224723 | 0.78 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL4727877 | 0.77 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL10085805 | 0.75 | RAB9A (0.74) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL13952300 | 0.72 | RAB9A (0.62) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL4225429 | 0.71 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL4727985 | 0.71 | KMT2A (1.00) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL1806107 | 0.71 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL4224669 | 0.71 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029168-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |