Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 11/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580394 | 0.86 | NCOA1 (0.54) | NCOA1NCOA3IKBKBMEN1APAF1 | |
| SCHEMBL4718101 | 0.82 | MEN1 (0.44) | MEN1APAF1KMT2AFEN1 | |
| SCHEMBL974439 | 0.80 | IKBKB (0.48) | NCOA1NCOA3IKBKBKCNH2SCN5A | |
| SCHEMBL28501185 | 0.77 | HSP90AA1 (0.53) | NCOA1NCOA3IKBKBALOX5APFEN1 | |
| SCHEMBL30507528 | 0.77 | HSP90AA1 (0.53) | NCOA1NCOA3IKBKBALOX5APFEN1 | |
| SCHEMBL1143083 | 0.75 | NCOA1 (0.78) | NCOA1NCOA3MEN1APAF1KMT2A | |
| SCHEMBL29992912 | 0.75 | NCOA1 (0.78) | NCOA1NCOA3MEN1APAF1KMT2A | |
| SCHEMBL2463736 | 0.73 | NCOA1 (0.75) | NCOA1NCOA3MEN1APAF1KMT2A | |
| SCHEMBL7257609 | 0.73 | NCOA1 (0.75) | NCOA1NCOA3MEN1APAF1KMT2A | |
| SCHEMBL580833 | 0.70 | CLK1 (0.49) | IKBKBMEN1KMT2AALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |