SCHEMBL4726175

SCHEMBL4726175

CN(C)c1ccc(/N=N/c2nccs2)c(O)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.68
MEN1 O00255 4/20 0.68
MAPT P10636 4/20 0.68
KMT2A Q03164 4/20 0.68
MAPK1 P28482 3/20 0.68
TDP1 Q9NUW8 3/20 0.68
KDM4E B2RXH2 3/20 0.68
POLB P06746 2/20 0.68
NPSR1 Q6W5P4 2/20 0.68
IDO1 P14902 1/20 0.68
TDO2 P48775 1/20 0.68
GFER P55789 1/20 0.68
KCNH2 Q12809 15/20 0.58
HSP90AA1 P07900 2/20 0.57
CCR6 P51684 1/20 0.57
RIOK2 Q9BVS4 2/20 0.51
RAB9A P51151 2/20 0.42
PAX8 Q06710 1/20 0.42
CASP1 P29466 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4726180 1.00 L3MBTL1 (0.68) L3MBTL1MEN1MAPTKMT2AMAPK1
SCHEMBL20280267 0.85 MAPT (0.63) L3MBTL1MEN1MAPTKMT2AMAPK1
SCHEMBL4778752 0.85 MAPT (0.63) L3MBTL1MEN1MAPTKMT2AMAPK1
SCHEMBL4778757 0.85 MAPT (0.63) L3MBTL1MEN1MAPTKMT2AMAPK1
SCHEMBL29349454 0.83 KDM4E (0.49) L3MBTL1MEN1MAPTKMT2AMAPK1
SCHEMBL8661708 0.83 KDM4E (0.49) L3MBTL1MEN1MAPTKMT2AMAPK1
SCHEMBL8755605 0.83 KDM4E (0.49) L3MBTL1MEN1MAPTKMT2AMAPK1
SCHEMBL1683188 0.81 MAPT (1.00) L3MBTL1MEN1MAPTKMT2AMAPK1
SCHEMBL1683189 0.81 MAPT (1.00) L3MBTL1MEN1MAPTKMT2AMAPK1
SCHEMBL30875594 0.81 MAPT (1.00) L3MBTL1MEN1MAPTKMT2AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190091688-A1 FLUIDIC DEVICES FOR CHROMATOGRAPHIC SEPARATION AND METHODS OF MAKING AND USING THE SAME OREGON STATE UNIVERSITY (US) 2019-03-28 US claimed
WO-2017210199-A1 FLUIDIC DEVICES FOR CHROMATOGRAPHIC SEPARATION AND METHODS OF MAKING AND USING THE SAME OREGON STATE UNIVERSITY (US) 2017-12-07 WO claimed
EP-1980850-A1 Reagent and Method for Detecting an Adulterant in an Aqueous Sample Quest Diagnostics Investments Incorporated (US) 2008-10-15 EP claimed
EP-3347001-B1 AZOPHENOLS AS ERG ONCOGENE INHIBITORS HENRY M JACKSON FOUND ADVANCEMENT MILITARY MEDICINE INC (US) 2023-07-26 EP disclosed
US-11389796-B2 Fluidic devices for chromatographic separation and methods of making and using the same OREGON STATE UNIVERSITY (US) 2022-07-19 US disclosed
US-20190091688-A1 FLUIDIC DEVICES FOR CHROMATOGRAPHIC SEPARATION AND METHODS OF MAKING AND USING THE SAME OREGON STATE UNIVERSITY (US) 2019-03-28 US disclosed
US-10238639-B2 Azophenols as ERG oncogene inhibitors THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) 2019-03-26 US disclosed
US-20180169074-A1 Azophenols as ERG Oncogene Inhibitors THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) 2018-06-21 US disclosed
WO-2017210199-A1 FLUIDIC DEVICES FOR CHROMATOGRAPHIC SEPARATION AND METHODS OF MAKING AND USING THE SAME OREGON STATE UNIVERSITY (US) 2017-12-07 WO disclosed
EP-1146062-B1 Method of producing crosslinkable silyl group-containing polyoxyalkylene polymers KANEKA CORP (JP) 2006-12-20 EP disclosed
US-6503995-B2 Hydrosilation KANEKA CORPORATION (JP) 2003-01-07 US disclosed
US-20020013427-A1 Method of producing crosslinkable silyl group-containing polyoxyalkylene polymers KANEKA CORPORATION (JP) 2002-01-31 US disclosed
EP-1146062-A1 Method of producing crosslinkable silyl group-containing polyoxyalkylene polymers Kaneka Corporation (JP) 2001-10-17 EP disclosed
US-5790627-A Method and apparatus for observing a specimen using an X-ray microscope RESEARCH DEVELOPMENT CORP. (JP) 1998-08-04 US disclosed
EP-0763512-A1 AIR BAG GAS GENERATING AGENT OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1997-03-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180169074-A1 Azophenols as ERG Oncogene Inhibitors ERG, ESR1, CBX2 L3MBTL1 2210/4885MEN1 1297/4885MAPT 4076/4885
US-10238639-B2 Azophenols as ERG oncogene inhibitors ERG, ESR1, CBX2 L3MBTL1 2210/4885MEN1 1297/4885MAPT 4076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.