SCHEMBL4726199

SCHEMBL4726199

COc1ccc(NC(=O)Nc2cc(-c3c(Br)cnn3C)c3occc3c2)cc1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 20/20 0.68
HTR2C P28335 19/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4728086 0.90 HTR2A (0.57) HTR2AHTR2C
SCHEMBL4726213 0.90 HTR2A (0.54) HTR2AHTR2C
SCHEMBL4727433 0.89 HTR2A (0.57) HTR2AHTR2C
SCHEMBL4780050 0.89 HTR2A (0.63) HTR2AHTR2C
SCHEMBL4728076 0.89 HTR2A (0.70) HTR2AHTR2C
SCHEMBL4781004 0.88 HTR2A (0.64) HTR2AHTR2C
SCHEMBL4726660 0.86 HTR2A (0.65) HTR2AHTR2C
SCHEMBL4727034 0.84 HTR2A (0.65) HTR2AHTR2C
SCHEMBL4729627 0.82 HTR2A (0.65) HTR2AHTR2C
SCHEMBL5056013 0.81 HTR2A (1.00) HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008027483-A1 BENZOFURAN DERIVATIVES AS MODULATORS OF THE 5-HT2A RECEPTOR ARENA PHARMACEUTICALS, INC. (US) 2008-03-06 WO claimed
WO-2008027483-A1 BENZOFURAN DERIVATIVES AS MODULATORS OF THE 5-HT2A RECEPTOR ARENA PHARMACEUTICALS, INC. (US) 2008-03-06 WO disclosed
WO-2008027483-A1 BENZOFURAN DERIVATIVES AS MODULATORS OF THE 5-HT2A RECEPTOR ARENA PHARMACEUTICALS, INC. (US) 2008-03-06 WO disclosed