Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725040 | 1.00 | PDE10A (0.44) | PDE10ACYP1A2KDM1AENPP1PIK3CD | |
| SCHEMBL4728469 | 0.93 | PDE10A (0.47) | PDE10ACYP1A2KDM1AENPP1PIK3CD | |
| SCHEMBL4728977 | 0.93 | PDE10A (0.47) | PDE10ACYP1A2KDM1AENPP1PIK3CD | |
| SCHEMBL4726967 | 0.91 | PDE10A (0.52) | PDE10ACYP1A2ENPP1 | |
| SCHEMBL4726394 | 0.91 | PDE10A (0.52) | PDE10ACYP1A2ENPP1 | |
| SCHEMBL4728463 | 0.90 | PDPK1 (0.46) | PDE10ACYP1A2ENPP1PIK3CDPIK3CA | |
| SCHEMBL4725063 | 0.90 | PDPK1 (0.46) | PDE10ACYP1A2ENPP1PIK3CDPIK3CA | |
| SCHEMBL4728934 | 0.83 | PDE10A (0.57) | PDE10ACYP1A2ENPP1PIK3CDPIK3CA | |
| SCHEMBL4727863 | 0.83 | PDE10A (0.57) | PDE10ACYP1A2ENPP1PIK3CDPIK3CA | |
| SCHEMBL4727531 | 0.83 | EGFR (0.46) | PDE10ACYP1A2ENPP1PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |