Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725063 | 1.00 | PDPK1 (0.46) | PDPK1ATMPDE10AENPP1PIK3CD | |
| SCHEMBL4728978 | 0.92 | PDE10A (0.49) | PDPK1ATMPDE10AENPP1PIK3CD | |
| SCHEMBL4725516 | 0.92 | PDE10A (0.49) | PDPK1ATMPDE10AENPP1PIK3CD | |
| SCHEMBL4728977 | 0.90 | PDE10A (0.47) | PDE10AENPP1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4728469 | 0.90 | PDE10A (0.47) | PDE10AENPP1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4726586 | 0.90 | PDE10A (0.44) | ATMPDE10AENPP1PIK3CDPIK3CA | |
| SCHEMBL4725040 | 0.90 | PDE10A (0.44) | ATMPDE10AENPP1PIK3CDPIK3CA | |
| SCHEMBL4727531 | 0.83 | EGFR (0.46) | PDE10AENPP1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4727502 | 0.83 | PDE10A (0.43) | PDE10APIK3CDPIK3CAPIK3CBMTOR | |
| SCHEMBL4725061 | 0.82 | ATM (0.57) | PDPK1ATMPDE10AENPP1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |