Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731776 | 0.97 | PTPN1 (0.51) | PTPN1PSMB5CYP4F2CYP4A11NR4A2 | |
| SCHEMBL4726653 | 0.86 | PTPN1 (0.60) | PTPN1CYP4F2CYP4A11NR4A2SIRT2 | |
| SCHEMBL14260788 | 0.86 | PTPN1 (0.53) | PTPN1CYP4F2CYP4A11NR4A2SMPD1 | |
| SCHEMBL14261277 | 0.85 | PTPN1 (0.54) | PTPN1CYP4F2CYP4A11NR4A2SIRT2 | |
| SCHEMBL4730123 | 0.84 | PTPN1 (0.66) | PTPN1PSMB5CYP4F2CYP4A11NR4A2 | |
| SCHEMBL14260784 | 0.81 | PTPN1 (0.56) | PTPN1CYP4F2CYP4A11NR4A2SIRT2 | |
| SCHEMBL4730504 | 0.76 | PTPN1 (0.65) | PTPN1PSMB5SMPD1SIRT2SIRT1 | |
| SCHEMBL4730857 | 0.76 | PTPN1 (0.51) | PTPN1FFAR1 | |
| SCHEMBL14260783 | 0.73 | PTPN1 (0.48) | PTPN1SIRT2SIRT1SIRT3 | |
| SCHEMBL14261225 | 0.72 | PTPN1 (0.76) | PTPN1NR4A2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | claimed |