Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.65 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 8/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | GNA15 | P30679 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730123 | 0.92 | PTPN1 (0.66) | PTPN1SIRT2SIRT1SIRT3PSMB5 | |
| SCHEMBL4726653 | 0.88 | PTPN1 (0.60) | PTPN1SIRT2SIRT1SIRT3PTGES | |
| SCHEMBL14260784 | 0.83 | PTPN1 (0.56) | PTPN1SIRT2SIRT1SIRT3PTGES | |
| SCHEMBL4730748 | 0.83 | PTPN1 (0.45) | PTPN1SIRT2SIRT1SIRT3MMP13 | |
| SCHEMBL14261277 | 0.83 | PTPN1 (0.54) | PTPN1SIRT2SIRT1ADAMTS4PTGES | |
| SCHEMBL14261224 | 0.82 | PTPN1 (0.76) | PTPN1ADAMTS4MMP13PTGESALOX5 | |
| SCHEMBL14261225 | 0.82 | PTPN1 (0.76) | PTPN1ADAMTS4MMP13PTGESALOX5 | |
| SCHEMBL14260788 | 0.82 | PTPN1 (0.53) | PTPN1SIRT2SIRT1ADAMTS4SMPD1 | |
| SCHEMBL6000633 | 0.82 | PTPN1 (0.43) | PTPN1SIRT2SIRT1SIRT3MMP13 | |
| SCHEMBL14260886 | 0.81 | PTPN1 (0.76) | PTPN1PTGESALOX5FFAR1GNA15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |