Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.62 |
| ▸ | PRKCG | P05129 | 4/20 | 0.62 |
| ▸ | PRKCB | P05771 | 4/20 | 0.62 |
| ▸ | PRKCA | P17252 | 4/20 | 0.62 |
| ▸ | PRKCH | P24723 | 4/20 | 0.62 |
| ▸ | PRKCI | P41743 | 4/20 | 0.62 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.62 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.62 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.62 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.62 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.59 |
| ▸ | PRKACA | P17612 | 3/20 | 0.58 |
| ▸ | PRKACG | P22612 | 3/20 | 0.58 |
| ▸ | PRKACB | P22694 | 3/20 | 0.58 |
| ▸ | CCR2 | P41597 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731780 | 0.93 | ROCK2 (0.64) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL4727306 | 0.89 | ROCK2 (0.61) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL4729584 | 0.89 | ROCK2 (0.59) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL4729409 | 0.87 | ROCK2 (0.60) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL4729716 | 0.86 | ROCK2 (0.70) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL4727862 | 0.86 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL4780906 | 0.84 | CYP3A4 (0.53) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL13391692 | 0.83 | ROCK2 (0.53) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL13754479 | 0.83 | ROCK2 (0.53) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL5086472 | 0.83 | ROCK2 (0.59) | CYP3A4PRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | CHDI, INCORPORATED | 2008-02-21 | — | — | US | disclosed |
| US-4798897-A | (AMINOALKYL)AMINOSULFONYL-SUBSTITUTED CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1989-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | HTT, SNCA, NLN | CYP3A4 4801/4885PRKD3 3105/4885PRKCG 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.