Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5086561 | 0.86 | POLB (0.54) | POLBROCK2ROCK1TP53KMT2A | |
| SCHEMBL7319387 | 0.79 | ROCK2 (0.68) | POLBROCK2ROCK1KMT2ACHRM1 | |
| SCHEMBL4725783 | 0.72 | TP53 (0.37) | ROCK2ROCK1TP53KMT2ABRD4 | |
| SCHEMBL4782719 | 0.70 | POLB (0.51) | POLBROCK2ROCK1TP53KMT2A | |
| SCHEMBL5083135 | 0.69 | CHRM1 (0.43) | POLBROCK2ROCK1TP53KMT2A | |
| SCHEMBL5086179 | 0.68 | ROCK2 (0.81) | ROCK2ROCK1TP53KMT2ACHRM1 | |
| SCHEMBL4726186 | 0.64 | CHRM1 (0.47) | POLBROCK2ROCK1TP53KMT2A | |
| SCHEMBL4726515 | 0.63 | ROCK2 (0.68) | ROCK2ROCK1TP53KMT2ACHRM1 | |
| SCHEMBL4782353 | 0.62 | CHRM1 (0.52) | POLBROCK2ROCK1TP53KMT2A | |
| SCHEMBL7317880 | 0.62 | CHRM1 (0.54) | POLBROCK2ROCK1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |