Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.52 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 5/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4836241 | 0.89 | FYN (0.60) | FYNMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4796523 | 0.82 | FYN (0.56) | FYNMAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL4333167 | 0.81 | PIK3CG (0.64) | FYNMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL1424116 | 0.80 | FYN (0.70) | FYNMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4338374 | 0.80 | PIK3CG (0.71) | FYNMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4326781 | 0.80 | FYN (0.66) | FYNMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4333345 | 0.78 | PIM1 (0.71) | FYNMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL1424073 | 0.78 | MAPT (0.74) | FYNMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4558600 | 0.78 | FYN (0.74) | FYNMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4328675 | 0.78 | FYN (0.80) | FYNMAPTSMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |