Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 6/20 | 0.56 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.54 |
| ▸ | ACVR2A | P27037 | 3/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595121 | 0.83 | FYN (0.77) | FYNTGFBR2ACVR2ATGFBR1JAK2 | |
| SCHEMBL4727573 | 0.82 | FYN (0.60) | FYNTGFBR2ACVR2ATGFBR1PIK3CG | |
| SCHEMBL4338930 | 0.81 | RET (0.59) | FYNTGFBR2ACVR2ATGFBR1PIM1 | |
| SCHEMBL4339409 | 0.80 | FYN (0.73) | FYNTGFBR2ACVR2ATGFBR1JAK2 | |
| SCHEMBL4836241 | 0.80 | FYN (0.60) | FYNTGFBR2ACVR2ATGFBR1PIK3CG | |
| SCHEMBL4330159 | 0.78 | PIK3CG (0.65) | FYNTGFBR2ACVR2ATGFBR1JAK2 | |
| SCHEMBL4694423 | 0.78 | PIK3CG (0.69) | FYNTGFBR2ACVR2ATGFBR1PIK3CG | |
| SCHEMBL4339522 | 0.77 | FYN (0.78) | FYNTGFBR2ACVR2ATGFBR1JAK2 | |
| SCHEMBL4344737 | 0.76 | FYN (0.67) | FYNTGFBR2ACVR2ATGFBR1PIK3CG | |
| SCHEMBL4334171 | 0.76 | FYN (0.78) | FYNTGFBR2ACVR2ATGFBR1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |