Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949026 | 0.81 | NFKB1 (0.61) | NFKB1PIK3CAPIK3CGABL1BCR | |
| SCHEMBL6954358 | 0.81 | KDR (0.47) | PIK3CAPIK3CGCDK2SYKTNNI3K | |
| SCHEMBL857003 | 0.80 | AURKA (0.50) | NFKB1ABL1CDK2SRCSYK | |
| SCHEMBL4726576 | 0.76 | KDR (0.49) | CDK2FLT1KDRRET | |
| SCHEMBL14088797 | 0.74 | PIK3CA (0.62) | NFKB1PIK3CAPIK3CGABL1BCR | |
| SCHEMBL762506 | 0.74 | NFKB1 (0.76) | NFKB1PIK3CAPIK3CGABL1BCR | |
| SCHEMBL30240628 | 0.74 | NFKB1 (0.76) | NFKB1PIK3CAPIK3CGABL1BCR | |
| Sulfuric Acid SCHEMBL7475143 | 0.73 | TNNI3K (0.54) | NFKB1PIK3CAPIK3CGABL1BCR | |
| SCHEMBL21443485 | 0.73 | AURKA (0.62) | NFKB1PIK3CAPIK3CGABL1BCR | |
| SCHEMBL28918013 | 0.73 | NFKB1 (0.51) | NFKB1PIK3CAPIK3CGCDK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |