Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 13/20 | 0.44 |
| ▸ | PRKDC | P78527 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | LDHB | P07195 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730225 | 0.81 | ATR (0.46) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1166941 | 0.77 | HCRTR2 (0.42) | — | |
| SCHEMBL4741394 | 0.75 | FOLH1 (0.46) | — | |
| SCHEMBL11906697 | 0.73 | ATR (0.72) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL408691 | 0.73 | GSK3B (0.61) | ATRPRKDC | |
| SCHEMBL13401182 | 0.73 | ATR (0.45) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL4731377 | 0.72 | ATR (0.40) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL16836772 | 0.72 | PTGER4 (0.48) | — | |
| SCHEMBL318797 | 0.71 | ATR (0.68) | ATRPRKDCATM | |
| SCHEMBL3983850 | 0.71 | ATR (0.72) | ATRPRKDCPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008038010-A1 | PYRAZINE DERIVATIVES AND THEIR USE IN THERAPY | VERNALIS (R & D) LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |