Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 15/20 | 0.46 |
| ▸ | PRKDC | P78527 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LDHB | P07195 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401182 | 0.84 | ATR (0.45) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL16836777 | 0.83 | PTGER4 (0.45) | — | |
| SCHEMBL3460775 | 0.83 | ATR (0.54) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL3459928 | 0.82 | ATR (0.53) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL4731377 | 0.81 | ATR (0.40) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL4728065 | 0.81 | ATR (0.44) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL23419672 | 0.80 | ATR (0.46) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL3460611 | 0.79 | ATR (0.56) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL23389810 | 0.79 | ATR (0.67) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1167034 | 0.78 | GSK3B (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| WO-2008038010-A1 | PYRAZINE DERIVATIVES AND THEIR USE IN THERAPY | VERNALIS (R & D) LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |