Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.45 |
| ▸ | NAMPT | P43490 | 6/20 | 0.45 |
| ▸ | ABHD6 | Q9BV23 | 6/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730749 | 0.82 | NOTUM (0.47) | NAMPTS1PR1 | |
| SCHEMBL25200985 | 0.80 | ESR1 (0.51) | ESR1ESR2ABHD6MGLLHDAC8 | |
| SCHEMBL565064 | 0.77 | ESR1 (0.58) | ESR1ESR2ABHD6S1PR1HDAC8 | |
| SCHEMBL1367276 | 0.75 | ESR1 (0.52) | ESR1ESR2ABHD6HDAC8HDAC6 | |
| SCHEMBL25199618 | 0.74 | ESR1 (0.57) | ESR1ESR2NAMPTABHD6HDAC8 | |
| SCHEMBL30412058 | 0.74 | ESR1 (0.57) | ESR1ESR2NAMPTABHD6HDAC8 | |
| SCHEMBL1366031 | 0.74 | ESR1 (0.48) | ESR1ESR2NAMPTABHD6MGLL | |
| SCHEMBL25604135 | 0.72 | ESR2 (0.77) | ESR1ESR2ABHD6HDAC8HDAC6 | |
| SCHEMBL13439632 | 0.72 | KCNJ1 (0.48) | ESR1ESR2NAMPTABHD6MGLL | |
| SCHEMBL5913288 | 0.71 | ESR1 (0.54) | ESR1ESR2NAMPTABHD6MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |