Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 8/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728102 | 0.82 | ESR1 (0.45) | NAMPTS1PR1 | |
| SCHEMBL12660102 | 0.79 | NOTUM (0.56) | NOTUMNAMPTHRH3RORC | |
| SCHEMBL14590650 | 0.77 | NOTUM (0.55) | NOTUMNAMPTRORC | |
| SCHEMBL4728167 | 0.76 | MCHR1 (0.50) | NOTUMHRH3 | |
| SCHEMBL14590628 | 0.75 | NAMPT (0.53) | NOTUMNAMPTHRH3RORC | |
| SCHEMBL14590652 | 0.74 | NAMPT (0.57) | NOTUMNAMPT | |
| SCHEMBL14590625 | 0.72 | NAMPT (0.49) | NOTUMNAMPTHRH3RORC | |
| SCHEMBL5766935 | 0.72 | NOTUM (0.49) | NOTUMNAMPT | |
| SCHEMBL16284194 | 0.72 | NOTUM (0.60) | NOTUMNAMPT | |
| SCHEMBL8203535 | 0.71 | NOTUM (0.56) | NOTUMHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |