SCHEMBL4728366

SCHEMBL4728366

COc1cc2ncn(C)c(=O)c2cc1OC

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 3/20 0.59
MAPK1 P28482 2/20 0.55
TSHR P16473 1/20 0.55
TNF P01375 3/20 0.54
KDM4E B2RXH2 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.48
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
ALDH1A1 P00352 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
IP6K1 Q92551 1/20 0.46
SRC P12931 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24165356 0.89 HDAC6 (0.49) HDAC6MAPK1TSHRTNFKDM4E
SCHEMBL23959931 0.89 HDAC6 (0.56) HDAC6MAPK1TSHRTNFKDM4E
SCHEMBL19645657 0.89 HDAC6 (0.56) HDAC6MAPK1TSHRTNFKDM4E
SCHEMBL19645642 0.87 HDAC6 (0.52) HDAC6MAPK1TSHRTNFKDM4E
SCHEMBL29377697 0.87 HDAC6 (0.48) HDAC6MAPK1TSHRTNFKDM4E
SCHEMBL28689988 0.87 HDAC6 (0.48) HDAC6MAPK1TSHRTNFKDM4E
SCHEMBL19645655 0.87 HDAC6 (0.51) HDAC6MAPK1TSHRTNFKDM4E
SCHEMBL4782862 0.87 HDAC6 (0.51) HDAC6MAPK1TSHRTNFKDM4E
SCHEMBL22323913 0.87 HDAC6 (0.48) HDAC6MAPK1TSHRTNFKDM4E
SCHEMBL24166144 0.85 HDAC6 (0.49) HDAC6MAPK1TSHRTNFKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008020302-A2 HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS PFIZER PRODUCTS INC. (US) 2008-02-21 WO disclosed