Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727748 | 0.92 | PDE10A (0.59) | PDE10ACYP1A2CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL4727502 | 0.90 | PDE10A (0.43) | PDE10ACYP1A2CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL4725039 | 0.89 | CYSLTR1 (0.57) | PDE10ACYP1A2CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL4725523 | 0.88 | PDE10A (0.56) | PDE10ACYP1A2CYSLTR2CYSLTR1 | |
| SCHEMBL4728978 | 0.83 | PDE10A (0.49) | PDE10ACYP1A2 | |
| SCHEMBL4725516 | 0.83 | PDE10A (0.49) | PDE10ACYP1A2 | |
| SCHEMBL4725560 | 0.82 | MAPK1 (0.50) | CYP1A2 | |
| SCHEMBL4725624 | 0.80 | PDE10A (0.60) | PDE10ACYP1A2CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL4783734 | 0.80 | PDE10A (0.59) | PDE10ACYP1A2CYSLTR2CYSLTR1 | |
| SCHEMBL4725187 | 0.79 | GPBAR1 (0.47) | PDE10ACYSLTR2CYSLTR1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |