Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | PLK1 | P53350 | 2/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | KIF15 | Q9NS87 | 2/20 | 0.53 |
| ▸ | ULK1 | O75385 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1394515 | 1.00 | RAF1 (0.60) | RAF1RETPLK4PLK1LRRK2 | |
| SCHEMBL5083186 | 0.86 | LRRK2 (0.73) | RAF1RETPLK4PLK1LRRK2 | |
| SCHEMBL1395239 | 0.86 | LRRK2 (0.73) | RAF1RETPLK4PLK1LRRK2 | |
| SCHEMBL1394877 | 0.86 | RET (0.60) | RAF1RETPLK4PLK1LRRK2 | |
| SCHEMBL5086182 | 0.86 | RET (0.60) | RAF1RETPLK4PLK1LRRK2 | |
| SCHEMBL1395409 | 0.80 | LRRK2 (0.76) | RAF1PLK4PLK1LRRK2KIF15 | |
| SCHEMBL1395411 | 0.80 | LRRK2 (0.76) | RAF1PLK4PLK1LRRK2KIF15 | |
| SCHEMBL1394501 | 0.80 | LRRK2 (0.70) | RAF1RETPLK4PLK1LRRK2 | |
| SCHEMBL1394503 | 0.80 | LRRK2 (0.70) | RAF1RETPLK4PLK1LRRK2 | |
| SCHEMBL1395085 | 0.78 | PLK4 (0.79) | RAF1PLK4PLK1LRRK2KIF15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | CHDI, INCORPORATED | 2008-02-21 | — | — | US | disclosed |
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | HTT, SNCA, NLN | RAF1 4132/4885RET 3696/4885PLK4 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.