Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 4/20 | 0.52 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | PLK1 | P53350 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | ARAF | P10398 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | MYOC | Q99972 | 1/20 | 0.52 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1394877 | 1.00 | RET (0.60) | RETLRRK2CES1RAF1MAP1LC3B | |
| SCHEMBL1394515 | 0.86 | RAF1 (0.60) | RETLRRK2CES1RAF1MAP1LC3B | |
| SCHEMBL1395239 | 0.86 | LRRK2 (0.73) | RETLRRK2CES1RAF1MAP1LC3B | |
| SCHEMBL5083186 | 0.86 | LRRK2 (0.73) | RETLRRK2CES1RAF1MAP1LC3B | |
| SCHEMBL4728586 | 0.86 | RAF1 (0.60) | RETLRRK2CES1RAF1MAP1LC3B | |
| SCHEMBL1394501 | 0.82 | LRRK2 (0.70) | RETLRRK2RAF1MAP1LC3BEGFR | |
| SCHEMBL1394503 | 0.82 | LRRK2 (0.70) | RETLRRK2RAF1MAP1LC3BEGFR | |
| SCHEMBL6690796 | 0.80 | RAF1 (0.76) | LRRK2RAF1MAP1LC3BEGFRPLK4 | |
| SCHEMBL4730059 | 0.80 | RET (0.55) | RETLRRK2CES1RAF1MAP1LC3B | |
| SCHEMBL1395237 | 0.80 | LRRK2 (0.61) | RETLRRK2RAF1MAP1LC3BEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | CHDI, INCORPORATED | 2008-02-21 | — | — | US | disclosed |
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | HTT, SNCA, NLN | RET 3696/4885LRRK2 408/4885CES1 2952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.