Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.77 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725226 | 0.96 | PDE3A (0.78) | PDE3APDE10APDE3BHTR1AHTR7 | |
| SCHEMBL4727792 | 0.88 | PDE3A (0.73) | PDE3APDE10APDE3BHTR1AHTR7 | |
| SCHEMBL5242098 | 0.87 | PDE3A (1.00) | PDE3APDE10APDE3BHTR1AHTR7 | |
| SCHEMBL5243398 | 0.87 | PDE3A (1.00) | PDE3APDE10APDE3BHTR1AHTR7 | |
| SCHEMBL4725590 | 0.84 | PDE3A (0.75) | PDE3APDE10APDE3BHTR1AHTR7 | |
| SCHEMBL4727752 | 0.83 | PDE3A (0.71) | PDE3APDE10APDE3BHTR1AHTR7 | |
| SCHEMBL4725096 | 0.81 | PDE3A (0.77) | PDE3APDE10APDE3BHTR1AHTR7 | |
| SCHEMBL4727937 | 0.80 | PDE3A (0.85) | PDE3APDE10APDE3BHTR1AHTR7 | |
| SCHEMBL5243437 | 0.78 | PDE3A (0.82) | PDE3APDE10APDE3BPRKDC | |
| SCHEMBL8273729 | 0.78 | PDE3A (0.82) | PDE3APDE10APDE3BPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |