Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.71 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727792 | 0.85 | PDE3A (0.73) | PDE3APDE10ATLR9TLR7HTR1A | |
| SCHEMBL5242098 | 0.84 | PDE3A (1.00) | PDE3APDE10AHTR1AHTR7PDE3B | |
| SCHEMBL4728652 | 0.83 | PDE3A (0.77) | PDE3APDE10ATLR9TLR7HTR1A | |
| SCHEMBL5243398 | 0.83 | PDE3A (1.00) | PDE3APDE10AHTR1AHTR7PDE3B | |
| SCHEMBL4725590 | 0.82 | PDE3A (0.75) | PDE3APDE10AHTR1AHTR7PDE3B | |
| SCHEMBL4725226 | 0.81 | PDE3A (0.78) | PDE3APDE10AHTR1AHTR7PDE3B | |
| SCHEMBL4725096 | 0.80 | PDE3A (0.77) | PDE3APDE10AHTR1AHTR7PDE3B | |
| SCHEMBL4729633 | 0.77 | EGFR (0.51) | PDE10A | |
| SCHEMBL4727937 | 0.77 | PDE3A (0.85) | PDE3APDE10AHTR1AHTR7PDE3B | |
| SCHEMBL4727225 | 0.76 | PDE3A (0.70) | PDE3APDE10AHTR1AHTR7KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |