Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 3/20 | 0.48 |
| ▸ | AGXT | P21549 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 7/20 | 0.45 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | UGCG | Q16739 | 1/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27089918 | 0.98 | L3MBTL1 (0.65) | L3MBTL1TDP1IDO1AGXTCA1 | |
| SCHEMBL1355360 | 0.98 | L3MBTL1 (0.65) | L3MBTL1TDP1IDO1AGXTCA1 | |
| SCHEMBL16727734 | 0.98 | L3MBTL1 (0.65) | L3MBTL1TDP1IDO1AGXTCA1 | |
| SCHEMBL6512199 | 0.95 | L3MBTL1 (0.59) | L3MBTL1TDP1IDO1AGXTCA1 | |
| SCHEMBL1427941 | 0.87 | TDP1 (0.54) | L3MBTL1TDP1IDO1AGXTCA1 | |
| SCHEMBL7230240 | 0.84 | TDP1 (0.53) | L3MBTL1TDP1IDO1CALM1NPC1 | |
| SCHEMBL17230523 | 0.84 | L3MBTL1 (0.64) | L3MBTL1TDP1IDO1AGXTCA1 | |
| SCHEMBL15233070 | 0.83 | TDP1 (0.63) | L3MBTL1TDP1IDO1AGXTCA1 | |
| SCHEMBL1354242 | 0.83 | L3MBTL1 (0.56) | L3MBTL1TDP1IDO1AGXTCA1 | |
| SCHEMBL9574168 | 0.83 | TDP1 (0.59) | L3MBTL1TDP1IDO1CALM1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113348164-B | Preparation method and intermediate of fused tricyclic derivative | 四川海思科制药有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-113348164-A | Preparation method and intermediate of fused tricyclic derivative | 四川海思科制药有限公司 | 2021-09-03 | — | — | CN | disclosed |
| WO-2020155952-A1 | PREPARATION METHOD FOR FUSED TRICYCLIC DERIVATIVE AND INTERMEDIATE | 四川海思科制药有限公司 | 2020-08-06 | — | — | WO | disclosed |
| WO-2008044033-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-04-17 | — | — | WO | disclosed |
| US-6531469-B1 | Treatment of myocardial ischemia, chronic stable angina, unstable angina and prinzmetal's angina attacks, silent cardiac ischemia, reinfarction, reocclusion and restenosis | PIERRE FABRE MEDICAMENT (FR) | 2003-03-11 | — | — | US | disclosed |
| EP-1144408-B1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PF MEDICAMENT (FR) | 2002-09-25 | — | — | EP | disclosed |
| EP-1144408-A1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PIERRE FABRE MEDICAMENT (FR) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043391-A1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PIERRE FABRE MEDICAMENT (FR) | 2000-07-27 | — | — | WO | disclosed |