Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728829 | 0.92 | GRM5 (0.47) | GRM5NTRK2CLK4DYRK1BTYRO3 | |
| SCHEMBL30041388 | 0.89 | GRM5 (0.58) | GRM5CLK4NTRK1FLT3GSK3B | |
| SCHEMBL30090707 | 0.77 | GABRP (0.34) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL17080815 | 0.72 | CA9 (0.46) | CA9 | |
| SCHEMBL4728825 | 0.71 | NTRK2 (0.45) | NTRK2CLK4DYRK1BTYRO3KDR | |
| SCHEMBL25215228 | 0.71 | CLK4 (0.51) | GRM5NTRK2CLK4DYRK1BTYRO3 | |
| SCHEMBL2041218 | 0.71 | NTRK2 (0.51) | GRM5NTRK2CLK4DYRK1BTYRO3 | |
| SCHEMBL29948230 | 0.71 | NTRK2 (0.51) | GRM5NTRK2CLK4DYRK1BTYRO3 | |
| SCHEMBL4730231 | 0.70 | NTRK2 (0.44) | NTRK2CLK4DYRK1BTYRO3KDR | |
| SCHEMBL28115873 | 0.69 | NTRK2 (0.49) | GRM5NTRK2CLK4DYRK1BTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |