Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.44 |
| ▸ | GABRE | P78334 | 2/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.44 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21415484 | 0.84 | KDM4E (0.46) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL28417296 | 0.83 | CES2 (0.45) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2930434 | 0.81 | KDM4E (0.50) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL489533 | 0.81 | HPGD (0.55) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10662412 | 0.79 | KDM4E (0.42) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1457096 | 0.79 | KDM4E (0.48) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30374425 | 0.79 | KDM4E (0.48) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL208161 | 0.78 | KDM4E (0.53) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL28950924 | 0.78 | KDM4E (0.52) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL27292205 | 0.78 | KDM4E (0.46) | KDM4EASPHKDM8HAAOCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11891371-B2 | Piperonylic acid derivative and preparation and application thereof | Shenyang Sinochem Agrochemicals R&D Co., LTD (CN) | 2024-02-06 | — | — | US | disclosed |
| EP-3647305-B1 | PIPERIC ACID DERIVATIVE AND PREPARATION AND APPLICATION THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R & D CO LTD (CN) | 2022-02-23 | — | — | EP | disclosed |
| US-20200181107-A1 | PIPERONYLIC ACID DERIVATIVE AND PREPARATION AND APPLICATION THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2020-06-11 | — | — | US | disclosed |
| EP-3647305-A1 | PIPERIC ACID DERIVATIVE AND PREPARATION AND APPLICATION THEREOF | Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) | 2020-05-06 | — | — | EP | disclosed |
| WO-2016059548-A1 | PROCESSES FOR THE PREPARATION OF DABRAFENIB | MYLAN LABORATORIES LTD (IN) | 2016-04-21 | — | — | WO | disclosed |
| US-20080207722-A1 | Glepp-1 Inhibitors in the Treatment of Autoimmune and/or Inflammatory Disorders | LABORATORIES SERONO SA (CH) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11891371-B2 | Piperonylic acid derivative and preparation and application thereof | CYP51A1, DDT, PIR | KDM4E 1003/4885GABRP 49/4885GABRD 127/4885 |
| US-20200181107-A1 | PIPERONYLIC ACID DERIVATIVE AND PREPARATION AND APPLICATION THEREOF | CYP51A1, DDT, PIR | KDM4E 1003/4885GABRP 49/4885GABRD 127/4885 |
| US-20080207722-A1 | Glepp-1 Inhibitors in the Treatment of Autoimmune and/or Inflammatory Disorders | PPP1R1B, PPP5C, PPP3CA | KDM4E 3799/4885GABRP 2083/4885GABRD 2088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.