Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.78 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482977 | 0.86 | HTR6 (0.77) | HTR6SLC6A4 | |
| SCHEMBL4671073 | 0.84 | HTR6 (0.74) | HTR6SLC6A4 | |
| SCHEMBL4670755 | 0.80 | HTR6 (0.78) | HTR6 | |
| SCHEMBL3340516 | 0.79 | HTR6 (0.78) | HTR6SLC6A4 | |
| SCHEMBL4673495 | 0.79 | HTR6 (0.59) | HTR6HTR1ASLC6A4 | |
| SCHEMBL4671006 | 0.75 | HTR6 (0.73) | HTR6SLC6A4 | |
| SCHEMBL4671230 | 0.75 | HTR6 (1.00) | HTR6SLC6A4 | |
| SCHEMBL3338901 | 0.74 | HTR6 (0.77) | HTR6HTR1A | |
| SCHEMBL4673875 | 0.74 | HTR6 (1.00) | HTR6HTR1A | |
| SCHEMBL7485051 | 0.73 | HTR6 (0.79) | HTR6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-B9 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2008-10-15 | — | — | EP | disclosed |
| EP-1173432-B1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2007-10-17 | — | — | EP | disclosed |