Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 12/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 9/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | PLK2 | Q9NYY3 | 8/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | TAF1 | P21675 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731448 | 0.91 | PLK1 (0.54) | PLK1PLK3BRD4PLK2MAPK7 | |
| SCHEMBL4730180 | 0.90 | PLK1 (0.54) | PLK1PLK3BRD4PLK2MAPK7 | |
| SCHEMBL4782180 | 0.90 | PLK1 (0.58) | PLK1PLK3BRD4PLK2EGFR | |
| SCHEMBL4844864 | 0.88 | PLK1 (0.52) | PLK1PLK3BRD4PLK2STK17A | |
| SCHEMBL4783694 | 0.88 | PLK1 (0.54) | PLK1PLK3BRD4PLK2MAPK7 | |
| SCHEMBL4800861 | 0.87 | PLK1 (0.60) | PLK1PLK3BRD4PLK2EGFR | |
| SCHEMBL4781914 | 0.86 | PLK1 (0.52) | PLK1PLK3BRD4PLK2MAPK7 | |
| SCHEMBL4729262 | 0.85 | PLK1 (0.56) | PLK1PLK3BRD4PLK2MAPK7 | |
| SCHEMBL4784445 | 0.85 | PLK1 (0.60) | PLK1PLK3BRD4PLK2JAK3 | |
| SCHEMBL4782049 | 0.84 | PLK1 (0.55) | PLK1PLK3BRD4PLK2MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |