Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.69 |
| ▸ | HSP90AB1 | P08238 | 11/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | TDP2 | O95551 | 1/20 | 0.69 |
| ▸ | FGB | P02675 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL11544230 | 0.94 | MEN1 (0.62) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| Pyrophosphoric Acid SCHEMBL11544226 | 0.91 | MEN1 (0.59) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL6270978 | 0.85 | MEN1 (0.66) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| Quinocide SCHEMBL157174 | 0.82 | MEN1 (1.00) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| Quinocide SCHEMBL29720457 | 0.82 | MEN1 (1.00) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| Quinocide SCHEMBL30823571 | 0.81 | HSP90AA1 (1.00) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| Quinocide SCHEMBL28060369 | 0.81 | HSP90AA1 (1.00) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| Quinocide SCHEMBL707955 | 0.81 | HSP90AA1 (1.00) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL11550294 | 0.79 | MEN1 (0.48) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL8384450 | 0.79 | NFKBIA (0.51) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | CHDI, INCORPORATED | 2008-02-21 | — | — | US | disclosed |
| US-4179561-A | REACTING A 3-DIAZOOXINDOLE WITH A SUBSTITUTED ACETYLENE | E. R. SQUIBB & SONS, INC. (US) | 1979-12-18 | — | — | US | disclosed |
| US-4167638-A | Process for production of 8-NHR quinolines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1979-09-11 | — | — | US | disclosed |
| US-4112096-A | ANTIALLERGENS | E. R. SQUIBB & SONS, INC. (US) | 1978-09-05 | — | — | US | disclosed |
| US-4076818-A | ANTIALLERGENS | E. R. SQUIBB & SONS, INC. (US) | 1978-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | HTT, SNCA, NLN | MEN1 3687/4885KMT2A 1354/4885HSP90AA1 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.