Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 15/20 | 0.75 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.75 |
| ▸ | ESRRG | P62508 | 7/20 | 0.55 |
| ▸ | ESRRB | O95718 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PLD2 | O14939 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.55 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.54 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726445 | 1.00 | ESR1 (0.75) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL16605498 | 1.00 | ESR1 (0.75) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL4727589 | 0.86 | ESR1 (0.62) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL21094252 | 0.86 | ESR1 (0.62) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL19700406 | 0.85 | ESR1 (0.60) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL20750711 | 0.84 | ESR1 (0.59) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL3468471 | 0.83 | ESR1 (0.66) | ESR1ESR2ESRRGPGRPSMB1 | |
| SCHEMBL4729921 | 0.81 | ESR1 (0.51) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL2477011 | 0.81 | ESR1 (0.65) | ESR1ESR2ESRRGESRRBKDM4E | |
| Hydrochloric Acid SCHEMBL4728833 | 0.80 | ESR1 (0.50) | ESR1ESR2ESRRGESRRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008030771-A1 | CYCLIC ALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-13 | — | — | WO | claimed |
| WO-2008030771-A1 | CYCLIC ALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-13 | — | — | WO | disclosed |
| WO-2008030771-A1 | CYCLIC ALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-13 | — | — | WO | disclosed |