Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.62 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.51 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ESRRG | P62508 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726445 | 0.86 | ESR1 (0.75) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL16605498 | 0.86 | ESR1 (0.75) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL4730296 | 0.86 | ESR1 (0.75) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL19700406 | 0.81 | ESR1 (0.60) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL4727589 | 0.81 | ESR1 (0.62) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL20750711 | 0.72 | ESR1 (0.59) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL3468471 | 0.69 | ESR1 (0.66) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL3468421 | 0.69 | ESR1 (0.52) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL19699727 | 0.68 | ESR1 (0.55) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL4729921 | 0.68 | ESR1 (0.51) | ESR1ESR2MAPTPGRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10874739-B2 | Near-IR light-cleavable conjugates and conjugate precursors | The Unites States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2020-12-29 | — | — | US | disclosed |
| US-20200121790-A1 | NEAR-IR LIGHT-CLEAVABLE CONJUGATES AND CONJUGATE PRECURSORS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICE (US) | 2020-04-23 | — | — | US | disclosed |
| US-10561729-B2 | Near-IR light-cleavable conjugates and conjugate precursors | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-02-18 | — | — | US | disclosed |
| US-20190167793-A1 | NEAR-IR LIGHT-CLEAVABLE CONJUGATES AND CONJUGATE PRECURSORS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICE (US) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190167793-A1 | NEAR-IR LIGHT-CLEAVABLE CONJUGATES AND CONJUGATE PRECURSORS | STRA6, ALDH1A2, DHFR | ESR1 1828/4885ESR2 2066/4885PSMB1 2643/4885 |
| US-10561729-B2 | Near-IR light-cleavable conjugates and conjugate precursors | STRA6, ALDH1A2, DHFR | ESR1 1828/4885ESR2 2066/4885PSMB1 2643/4885 |
| US-20200121790-A1 | NEAR-IR LIGHT-CLEAVABLE CONJUGATES AND CONJUGATE PRECURSORS | STRA6, ALDH1A2, DHFR | ESR1 1828/4885ESR2 2066/4885PSMB1 2643/4885 |
| US-10874739-B2 | Near-IR light-cleavable conjugates and conjugate precursors | STRA6, ALDH1A2, DHFR | ESR1 1828/4885ESR2 2066/4885PSMB1 2643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.