Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 7/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.36 |
| ▸ | MMP13 | P45452 | 5/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000633 | 0.94 | PTPN1 (0.43) | PTPN1PTPN2SIRT2SIRT3SIRT1 | |
| SCHEMBL4728519 | 0.92 | PTPN1 (0.47) | PTPN1PTPN2SIRT2SIRT3SIRT1 | |
| SCHEMBL5999251 | 0.86 | PTPN1 (0.44) | PTPN1PTPN2MMP13ALOX5SMN1; SMN2 | |
| SCHEMBL6000654 | 0.86 | PTPN1 (0.42) | PTPN1PTPN2SIRT2SIRT3SIRT1 | |
| SCHEMBL4730504 | 0.83 | PTPN1 (0.65) | PTPN1SIRT2SIRT3SIRT1MMP13 | |
| SCHEMBL6000652 | 0.81 | PTPN2 (0.54) | PTPN1PTPN2SIRT2SIRT3SIRT1 | |
| SCHEMBL5999470 | 0.81 | PTPN1 (0.49) | PTPN1PTPN2MMP13ALOX5SMN1; SMN2 | |
| SCHEMBL6000958 | 0.79 | PTPN1 (0.44) | PTPN1PTPN2ALOX5SMN1; SMN2PPARD | |
| SCHEMBL6000020 | 0.78 | PTPN1 (0.48) | PTPN1PTPN2ALOX5PPARDPPARA | |
| SCHEMBL6000167 | 0.77 | PTPN1 (0.49) | PTPN1PTPN2MMP13ALOX5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |